Buy Pseudoephedrine a sympathomimetic amine – that is, its principal mechanism of action relies on its indirect action on the adrenergic receptor system. While it may have weak agonist activity at alpha and beta adrenergic receptors, the principal mechanism is to displace noradrenaline from storage vesicles in presynaptic neurons. The displaced noradrenaline is released into the neuronal synapse where it is free to activate the aforementioned postsynaptic adrenergic receptors.
Moreover An alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used in the treatment of several disorders including asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.
Furthermore Pseudoephedrine is a sympathomimetic agent, structurally similar to ephedrine. Pseudoephedrine (commonly abbreviated as PSE) is a sympathomimetic amine commonly used as a decongestant. Also Pseudoephedrine acts directly on both alpha- and, to a lesser degree, beta-adrenergic receptors. Furthermore Through direct action on alpha-adrenergic receptors in the mucosa of the respiratory tract, pseudo-ephedrine produces vasoconstriction.
Also Pseudo ephedrine relaxes bronchial smooth muscle by stimulating beta2-adrenergic receptors. Like ephedrine, pseudoephedrine releasing norepinephrine from its storage sites, an indirect effect. Whereas This is its main and direct mechanism of action. The other noradrenaline is into the neuronal synapse where it is free to activate the postsynaptic adrenergic receptors. General Manufacturing Information:
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IUPAC Name: (1S,2S)-2-(methylamino)-1-phenylpropan-1-ol
Molecular Formula: C10H15NO
Melting Point: 119 °C
Water Solubility: 7 mg/L (at 30 °C)
Appearance: White crystalline powder
Methods of Manufacturing:
Although pseudoephedrine occurs naturally as an alkaloid in certain plant species (for example, as a constituent of extracts from the ephedra species, refer to as Ma Huang, in which it occurs together with other isomers of ephedrine). Also the majority of pseudoephedrine for commercial use is from yeast fermentation of dextrose in the presence of benzaldehyde.
Also In this process, specialized strains of yeast (typically a variety of Candida utilis or Saccharomyces cerevisiae) are in combination with large vats containing water, dextrose and the enzyme pyruvate decarboxylase (such as those in beets and other plants, inter alia). Finally when the yeast begins fermenting the dextrose, the benzaldehyde is put with the vats, and in this environment the yeast convert the precursor ingredients to L-phenylacetylcarbinol. L-phenylacetylcarbinol/ is then chemically to pseudoephedrine via reductive amination.
Pseudoephedrine preparation should generally be be at 15-30 deg C avoid light, moisture.