Buy Ergotamine an ergopeptine and part of the ergot family. It is an alpha-1 selective adrenergic agonist and is commonly in use in the treatment of migraine disorders. Also Ergotamine is metabolized by the liver by large pathways, and 90% of the metabolites are come out in the bile.
Ergotamine acts on migraine by one of two proposed mechanisms:
- Activation of 5-HT1D receptors on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache.
- Also Activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.IUPAC Name: (5’α)-5′-Benzyl-12′-hydroxy-2′-methyl-3′,6′,18-trioxoergotamanMolecular Formula: C33H35N5O5
Melting Point: 213.5 °C
Water Solubility: slidely soluble, 2.23e-01 g/L
Storage: Best at room cool temperatures (25 deg C) and protect from light, moisture.
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