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What is Methaphetamine?

METHAMPHETAMINE is a central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. Also a synthetic substance. Normally seen as a white powder, it acts as a stimulant of the central nervous system (CNS). It is under international control and closely related to amphetamine. Whereas the smokable form is a drug of abuse and is referred to as crank, crystal, crystal meth, ice, and speed.

Methamphetamine is an Amphetamine Anorectic and Central Nervous System Stimulant. Also physiologic effect of methamphetamine is by means of Appetite Suppression and Central Nervous System Stimulation and Increased Sympathetic Activity. The chemical classification of methamphetamine is Amphetamines.

Methamphetamine is an amphetamine with central nervous system (CNS) stimulating activity. Further Methamphetamine acts by both facilitating the release of catecholamines, particularly noradrenaline, dopamine and serotonin, from nerve terminals in the brain and by inhibiting their uptake. Also this leads to an increase in synaptic concentration of these neurotransmitters and results in increased stimulation of postsynaptic receptors. Methamphetamine properly refers to a specific chemical, the racemic free base, which is an equal mixture of levomethamphetamine and dextromethamphetamine in their pure amine forms. However it is rarely prescribed due to concerns involving human neurotoxicity and potential for recreational use as an aphrodisiac and euphoriant, among other concerns, as well as the availability of safer substitute drugs with comparable treatment efficacy. Dextromethamphetamine is a much stronger CNS stimulant than levomethamphetamine.

Chemistry

Methamphetamine (CAS-537-46-2) is a member of the phenethylamine family, which includes a range of substances that may be stimulants, entactogens or hallucinogens. Thus, methamphetamine is N,α-dimethylphenethylamine.

Also according to IUPAC, the fully systematic name is N,α-dimethylbenzeneethanamine. Asymmetric α-carbon atom gives rise to two enantiomers. Finally These two forms were previously called the [–]- or lstereoisomer and the [+]- or d-stereoisomer, but in modern usage are defined as the R- and S-stereoisomers.

Pharmacology

Methamphetamine is a potent central nervous system stimulant which affects neurochemical mechanisms responsible for regulating heart rate, body temperature, blood pressure, appetite, attention, mood and responses associated with alertness or alarm conditions. Furthermore acute effects of the drug closely resemble the physiological and psychological effects of an epinephrine-provoked fight-or-flight response, including increased heart rate and blood pressure, vasoconstriction (constriction of the arterial walls), bronchodilation, and hyperglycemia (increased blood sugar). However users experience an increase in focus, increased mental alertness, and the elimination of fatigue, as well as a decrease in appetite.

Methamphetamine is an amphetamine with central nervous system (CNS) stimulating activity. Also Methamphetamine acts by both facilitating the release of catecholamines, particularly noradrenaline, dopamine and serotonin, from nerve terminals in the brain and by inhibiting their uptake. This leads to an increase in synaptic concentration of these neurotransmitters and results in increases in stimulation of postsynaptic receptors. Methamphetamine is a CNS stimulant that causes hypertension and tachycardia with feelings increases confidence, sociability and energy. It suppresses appetite and fatigue and leads to insomnia. Following oral use, the effects usually start within 30 minutes and last for many hours. Later, users may feel irritable, restless, anxious, depressed and lethargic. It increases the activity of the noradrenergic and dopamine neurotransmitter systems.

Synthesis and precursors

The S-enantiomer is most commonly from reduction of l-ephedrine, i.e. (1R,2S)-2-methylamino-1-phenylpropan-1-ol, or by reduction of d-pseudoephedrine, i.e. (1S,2S)-2-methylamino-1-phenylpropan-1-ol. Ephedrine and pseudoephedrine are commercially available and are in certain medicinal products. Ephedrine may also be from the plant Ephedra vulgaris L. (used in Chinese medicine as Ma Huang). Both the Leuckart route and reductive amination (e.g. the aluminium foil method) of 1-phenyl-2-propanone (P2P, BMK, phenylacetone) yield a racemic mixture of the R- and S-enantiomers. The synthetic route used may be identified by impurity profiling.

Therapeutic Uses

Adrenergic Agents; Adrenergic Uptake Inhibitors; Appetite Depressants; Central Nervous System Stimulants; Dopamine Agents; Dopamine Uptake Inhibitors; Sympathomimetics

Also National Library of Medicine’s Medical Subject Headings. Methamphetamine. Online file (MeSH, 2015). Available from, as of November 23, 2015: https://www.nlm.nih.gov/mesh/MBrowser.html

Also /CLINICAL TRIALS/ ClinicalTrials.gov is a registry and results database publicly and privately supports clinical studies of human participants conduction around the world. Each ClinicalTrials.gov record presents summary information about a study protocol and includes the following: Disease or condition; Intervention. Title, description, and design of the study; Requirements for participation (eligibility criteria);  and Links to relevant information on other health Web sites, such as NLM’s MedlinePlus for patient health information and PubMeds for citations and abstracts for scholarly articles in the field of medicine.

Furthermore NIH/NLM; ClinicalTrials.Gov. Available from, as of September 30, 2015: https://clinicaltrials.gov/search/intervention=Methamphetamine

Our Methamphetamine also is as an adjunct to psychological, educational, social, and other remedial measures in the treatment of attention deficit hyperactivity disorder (ADHD).

Effects

Effects of Methamphetamine range from increased physical activity, decreases appetite, alertness, increases heart rate and blood pressure, hyperthermia, paranoia, confusion, anxiety, aggressiveness, insomnia, tremors, and irritability.

Finally long Term effects range from violent behavior, mood disturbances, delusions, psychotic behavior, and hallucinations, Schizophrenia, Strokes and Alzheimer’s disease.

Metabolism/Metabolites

Hepatic. Primary site of metabolism is in the liver by aromatic hydroxylation, N-dealkylation and deamination. At least seven metabolites have been identified in the urine, with the main metabolites being amphetamine (active) and 4-hydroxymethamphetamine. Also Other minor metabolites include 4-hydroxyamphetamine, norephedrine, and 4-hydroxynorephedrine.

Methamphetamine is metabolizes in the liver by aromatic hydroxylation, N-dealkylation, and deamination; at least 7 metabolites have been identified in urine.

Furthermore a species difference is found in a study of the metabolism of methamphetamine, (+/-)-2-methylamino-1-phenylpropane. In man, 22% of an oral dose was excreted into urine same, & 15% of the dose was excreted as 4-hydroxymethamphetamine. Finally After ip admin to rat, 4-hydroxymethamphetamine was principal urinary metabolite (31% of dose), together with 4-hydroxynorephedrine (16%) & unchanged drug (11% of dose). In the guinea pig an ip dose was extensively metabolized to benzoic acid & its glycine & glucuronic acid conjugates.

 

 

 

 

 

References

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